Novel Origin of the 1918 Pandemic Influenza Virus Nucleoprotein Gene
Identifieur interne : 001656 ( Main/Exploration ); précédent : 001655; suivant : 001657Novel Origin of the 1918 Pandemic Influenza Virus Nucleoprotein Gene
Auteurs : Ann H. Reid [États-Unis] ; Thomas G. Fanning [États-Unis] ; Thomas A. Janczewski [États-Unis] ; Raina M. Lourens [États-Unis] ; Jeffery K. Taubenberger [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2004.
Abstract
The nucleoprotein (NP) gene of the 1918 pandemic influenza A virus has been amplified and sequenced from archival material. The NP gene is known to be involved in many aspects of viral function and to interact with host proteins, thereby playing a role in host specificity. The 1918 NP amino acid sequence differs at only six amino acids from avian consensus sequences, consistent with reassortment from an avian source shortly before 1918. However, the nucleotide sequence of the 1918 NP gene has more than 170 differences from avian strain consensus sequences, suggesting substantial evolutionary distance from known avian strain sequences. Both the gene and protein sequences of the 1918 NP fall within the mammalian clade upon phylogenetic analysis. The evolutionary distance of the 1918 NP sequences from avian and mammalian strain sequences is examined, using several different parameters. The results suggest that the 1918 strain did not retain the previously circulating human NP. Nor is it likely to have obtained its NP by reassortment with an avian strain similar to those now characterized. The results are consistent with the existence of a currently unknown host for influenza, with an NP similar to current avian strain NPs at the amino acid level but with many synonymous nucleotide differences, suggesting evolutionary isolation from the currently characterized avian influenza virus gene pool.
Url:
DOI: 10.1128/JVI.78.22.12462-12470.2004
PubMed: 15507633
PubMed Central: 525067
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000379
- to stream Pmc, to step Curation: 000379
- to stream Pmc, to step Checkpoint: 000C42
- to stream Ncbi, to step Merge: 000113
- to stream Ncbi, to step Curation: 000113
- to stream Ncbi, to step Checkpoint: 000113
- to stream Main, to step Merge: 001686
- to stream Main, to step Curation: 001656
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel Origin of the 1918 Pandemic Influenza Virus Nucleoprotein Gene</title>
<author><name sortKey="Reid, Ann H" sort="Reid, Ann H" uniqKey="Reid A" first="Ann H." last="Reid">Ann H. Reid</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fanning, Thomas G" sort="Fanning, Thomas G" uniqKey="Fanning T" first="Thomas G." last="Fanning">Thomas G. Fanning</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Janczewski, Thomas A" sort="Janczewski, Thomas A" uniqKey="Janczewski T" first="Thomas A." last="Janczewski">Thomas A. Janczewski</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lourens, Raina M" sort="Lourens, Raina M" uniqKey="Lourens R" first="Raina M." last="Lourens">Raina M. Lourens</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">15507633</idno>
<idno type="pmc">525067</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525067</idno>
<idno type="RBID">PMC:525067</idno>
<idno type="doi">10.1128/JVI.78.22.12462-12470.2004</idno>
<date when="2004">2004</date>
<idno type="wicri:Area/Pmc/Corpus">000379</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000379</idno>
<idno type="wicri:Area/Pmc/Curation">000379</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000379</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C42</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C42</idno>
<idno type="wicri:Area/Ncbi/Merge">000113</idno>
<idno type="wicri:Area/Ncbi/Curation">000113</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000113</idno>
<idno type="wicri:doubleKey">0022-538X:2004:Reid A:novel:origin:of</idno>
<idno type="wicri:Area/Main/Merge">001686</idno>
<idno type="wicri:Area/Main/Curation">001656</idno>
<idno type="wicri:Area/Main/Exploration">001656</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel Origin of the 1918 Pandemic Influenza Virus Nucleoprotein Gene</title>
<author><name sortKey="Reid, Ann H" sort="Reid, Ann H" uniqKey="Reid A" first="Ann H." last="Reid">Ann H. Reid</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fanning, Thomas G" sort="Fanning, Thomas G" uniqKey="Fanning T" first="Thomas G." last="Fanning">Thomas G. Fanning</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Janczewski, Thomas A" sort="Janczewski, Thomas A" uniqKey="Janczewski T" first="Thomas A." last="Janczewski">Thomas A. Janczewski</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lourens, Raina M" sort="Lourens, Raina M" uniqKey="Lourens R" first="Raina M." last="Lourens">Raina M. Lourens</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
<affiliation wicri:level="2"><nlm:aff id="aff0">Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The nucleoprotein (NP) gene of the 1918 pandemic influenza A virus has been amplified and sequenced from archival material. The NP gene is known to be involved in many aspects of viral function and to interact with host proteins, thereby playing a role in host specificity. The 1918 NP amino acid sequence differs at only six amino acids from avian consensus sequences, consistent with reassortment from an avian source shortly before 1918. However, the nucleotide sequence of the 1918 NP gene has more than 170 differences from avian strain consensus sequences, suggesting substantial evolutionary distance from known avian strain sequences. Both the gene and protein sequences of the 1918 NP fall within the mammalian clade upon phylogenetic analysis. The evolutionary distance of the 1918 NP sequences from avian and mammalian strain sequences is examined, using several different parameters. The results suggest that the 1918 strain did not retain the previously circulating human NP. Nor is it likely to have obtained its NP by reassortment with an avian strain similar to those now characterized. The results are consistent with the existence of a currently unknown host for influenza, with an NP similar to current avian strain NPs at the amino acid level but with many synonymous nucleotide differences, suggesting evolutionary isolation from the currently characterized avian influenza virus gene pool.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Reid, Ann H" sort="Reid, Ann H" uniqKey="Reid A" first="Ann H." last="Reid">Ann H. Reid</name>
</region>
<name sortKey="Fanning, Thomas G" sort="Fanning, Thomas G" uniqKey="Fanning T" first="Thomas G." last="Fanning">Thomas G. Fanning</name>
<name sortKey="Janczewski, Thomas A" sort="Janczewski, Thomas A" uniqKey="Janczewski T" first="Thomas A." last="Janczewski">Thomas A. Janczewski</name>
<name sortKey="Lourens, Raina M" sort="Lourens, Raina M" uniqKey="Lourens R" first="Raina M." last="Lourens">Raina M. Lourens</name>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001656 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001656 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:525067 |texte= Novel Origin of the 1918 Pandemic Influenza Virus Nucleoprotein Gene }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:15507633" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |